Prime Day supplement deals are back for October—here are the best discounts

Stock up on protein powders, vitamin gummies and more with the best Prime Day supplement deals

Two people taking supplements at home
(Image credit: Getty Images)

Amazon’s October sales event has just launched, which means more Prime Day supplement deals for money-savvy customers.

The two-day surprise event—technically called Prime Big Deal Days—runs from the 10th to the 11th of October and is exclusively for Prime members. Although it's well-known for offering savings on technology, it's also a great time to bulk buy protein powder and vitamin supplements. 

We’ve spent a lot of time testing and reviewing these types of products, guzzling everything from the best menopause supplements to supplements to ease joint pain. As such, we know what makes a good supplement—something palatable and not too pricey.

Using our testing experience, we’ve scoped out the best Prime Day supplement deals right now. We don't know how long these deals will be around for, so stock up quickly. But don't worry if your favorite supplements aren't featured below—Black Friday discounts are only a month away.

Prime Day retailer quick links

Prime Day protein deals

Myprotein US: Up to 45% off all protein powders at Myprotein

Myprotein US: <a href="https://www.awin1.com/awclick.php?awinmid=3196&awinaffid=103504&clickref=hawk-custom-tracking&p=https%3A%2F%2Fus.myprotein.com%2F" data-link-merchant="myprotein.com"" target="_blank" rel="nofollow">Up to 45% off all protein powders at Myprotein

Save up to 45% Although Prime Day is Amazon's event, Myprotein has got in on the action, offering 45% off when you spend $100 or more, making now a great time to bulk buy protein powders, bars, and snacks. No code needed.

Nutricost Creatine Monohydrate Micronized Powder:&nbsp;was $32.95,now $16.43 at Amazon&nbsp;

Nutricost Creatine Monohydrate Micronized Powder: was $32.95, now <a href="https://target.georiot.com/Proxy.ashx?tsid=110083&GR_URL=https%3A%2F%2Famazon.com%2FNutricost-Creatine-Monohydrate-Micronized-Powder%2Fdp%2FB00GL2HMES%3Ftag%3Dhawk-future-20%26ascsubtag%3Dhawk-custom-tracking-20" data-link-merchant="Amazon US"" target="_blank">$16.43 at Amazon 

Save $16.43 This protein powder is an ideal choice if you're looking to increase strength and promote muscle growth. This product is sourced from the highest quality ingredients, purity tested to make sure it’s free from contaminants.

Price check: <a href="https://goto.walmart.com/c/1943169/565706/9383?subId1=hawk-custom-tracking&sharedId=hawk&u=https%3A%2F%2Fwww.walmart.com%2Fip%2FNutricost-Creatine-Monohydrate-Powder-500-Grams-Unflavored-Supplement%2F451407919" data-link-merchant="walmart.com"" data-link-merchant="Amazon US"" target="_blank" rel="nofollow">Walmart $18.80

Dymatize ISO100 Hydrolyzed Protein Powder:was $33.47,&nbsp;now $23.42 at Amazon

Dymatize ISO100 Hydrolyzed Protein Powder: was $33.47, now <a href="https://target.georiot.com/Proxy.ashx?tsid=110083&GR_URL=https%3A%2F%2Famazon.com%2FDymatize-Hydrolyzed-Absorbing-Digesting-Chocolate%2Fdp%2FB099HXNRKK%3Ftag%3Dhawk-future-20%26ascsubtag%3Dhawk-custom-tracking-20" data-link-merchant="Amazon US"" target="_blank">$23.42 at Amazon

Save 30%. One of our favorite protein powders, this fast-absorbing, easy-digesting powder has 25 grams of high-quality protein from 100% whey protein isolate per serving. Each serving of ISO100 contains 120 calories or less, less than 1 gram of sugar, and 3 grams or less of carbs.

Nutricost Whey Protein Isolate Salted Caramel:&nbsp;was $113.95,&nbsp;now $48.90 at Amazon

Nutricost Whey Protein Isolate Salted Caramel: was $113.95, now <a href="https://target.georiot.com/Proxy.ashx?tsid=110083&GR_URL=https%3A%2F%2Famazon.com%2FNutricost-Protein-Isolate-Salted-Caramel%2Fdp%2FB07XZLZ6RV%2F%3Ftag%3Dhawk-future-20%26ascsubtag%3Dhawk-custom-tracking-20" data-link-merchant="Amazon US"" target="_blank">$48.90 at Amazon

Save 57%. Stock up your pantry and save on this low-calorie whey protein isolate from Nutricost. Each 5lb tub contains 62 servings, with each one providing 30g of high-quality protein with just 1g of sugar and 0.5g of fat. This indulgent blend is also free from GMOs and gluten.

Price check:  <a href="https://goto.target.com/c/221109/81938/2092?subId1=hawk-custom-tracking&sharedId=hawk&u=https%3A%2F%2Fwww.target.com%2Fp%2Fnutricost-whey-protein-isolate-powder-5-lb%2F-%2FA-89908581" data-link-merchant="target.com"" data-link-merchant="Amazon US"" target="_blank">Target $74.95 (unflavored) | <a href="https://goto.walmart.com/c/1943169/565706/9383?subId1=hawk-custom-tracking&sharedId=hawk&u=https%3A%2F%2Fwww.walmart.com%2Fip%2FNutricost-Whey-Protein-Isolate-Powder-Salted-Caramel-5LBS-Gluten-Free-Non-GMO%2F646216187" data-link-merchant="walmart.com"" data-link-merchant="target.com"" data-link-merchant="Amazon US"" target="_blank">Walmart $69.95 

Ora Organic Vegan Protein Powder Vanilla Chai Flavor: &nbsp;was $50.00,now $29.99 at Amazon

Ora Organic Vegan Protein Powder Vanilla Chai Flavor:  was $50.00, now <a href="https://target.georiot.com/Proxy.ashx?tsid=110083&GR_URL=https%3A%2F%2Famazon.com%2FOra-Organic-Vegan-Protein-Powder%2Fdp%2FB07HZ7YDDN%2F%3Ftag%3Dhawk-future-20%26ascsubtag%3Dhawk-custom-tracking-20" data-link-merchant="Amazon US"" target="_blank" rel="nofollow">$29.99 at Amazon 

Save $20. Keto-friendly and free from artificial ingredients, this high-quality blend provides 21g of pea protein and 120 calories per serving. Comes with added digestive enzymes and extracts from superfoods, such as kale, turmeric and acai berries.  

Vega Sport Premium Vegan Protein Powder Chocolate:&nbsp;was $46.99,&nbsp;now $32.89 at Amazon

Vega Sport Premium Vegan Protein Powder Chocolate: was $46.99, now<a href="https://target.georiot.com/Proxy.ashx?tsid=110083&GR_URL=https%3A%2F%2Famazon.com%2FVega-Protein-Powder-Chocolate-Servings%2Fdp%2FB016D9IHZG%3Ftag%3Dhawk-future-20%26ascsubtag%3Dhawk-custom-tracking-20" data-link-merchant="Amazon US"" target="_blank" rel="nofollow"> $32.89 at Amazon

Save $14.10. Don't miss out on this huge 30% saving before the deal ends! Each serving of the Vega Sport Premium Vegan Protein Powder offers a whopping 30g of complete protein, 2 billion CFUs of probiotics and just 1g of sugar. Free from GMOs, gluten and artificial sweeteners, this tasty blend will aid your weight loss and elevate your exercise performance.    

Premier Protein Powder Vanilla Milkshake: was $26.99now $25.18 at Amazon

Premier Protein Powder Vanilla Milkshake: was $26.99, now <a href="https://target.georiot.com/Proxy.ashx?tsid=110083&GR_URL=https%3A%2F%2Famazon.com%2FPremier-Protein-Whey-Powder-Vanilla%2Fdp%2FB06ZZ3PJQD%2F%3Ftag%3Dhawk-future-20%26ascsubtag%3Dhawk-custom-tracking-20" data-link-merchant="Amazon US"" target="_blank" rel="nofollow">$25.18 at Amazon 

Save 7%. With nearly 30g of high-quality protein and only 1g of sugar and 150 calories per serving, Premier Protein Powder will support your weight loss goals and supercharge your exercise performance. 

CBUM RAW Itholate Protein Powder Birthday Cake: was $40.95,now $35.24 at Amazon

CBUM RAW Itholate Protein Powder Birthday Cake: was $40.95, now <a href="https://target.georiot.com/Proxy.ashx?tsid=110083&GR_URL=https%3A%2F%2Famazon.com%2F-RAW-Whey-Isolate-Protein-Powder-Mint-Chip-Ice-Cream-CBUM-Grass-Fed%2Fdp%2FB0BYLVCCY3%2F%3Fth%3D1%26tag%3Dhawk-future-20%26ascsubtag%3Dhawk-custom-tracking-20" data-link-merchant="Amazon US"" target="_blank">$35.24 at Amazon 

Save 14%. Bored of vanilla and chocolate flavors? Then you can't miss this deal! CBUM RAW Itholate Protein Powder in flavor Birthday Cake is now 17% off on Amazon. Each serving provides a hefty 25g of high-quality whey protein isolate and only 150 calories. Free from artificial ingredients, GMOs, hormones and fillers. 

Orgain Organic Vegan Protein Powder: was $22.99, now $22.49 on Amazon

Orgain Organic Vegan Protein Powder: was $22.99, <a href="https://target.georiot.com/Proxy.ashx?tsid=110083&GR_URL=https%3A%2F%2Famazon.com%2FOrgain-Organic-Protein-Superfoods-Vanilla%2Fdp%2FB07PVKBGV3%3Fth%3D1%26tag%3Dhawk-future-20%26ascsubtag%3Dhawk-custom-tracking-20" data-link-merchant="Amazon US"" target="_blank" rel="nofollow">now $22.49 on Amazon

Save $7.50. This organic vegan protein powder in flavor Creamy Chocolate Fudge is is at its lowest ever price this Amazon Prime Day, saving you 25% although there are several other flavors to choose from. There's 21g of plant-based protein in each serving and only 1g of sugar. 

Prime Day supplement deals

Vital Proteins Collagen Peptides: was $51.00,&nbsp;now $32.49 at Amazon

Vital Proteins Collagen Peptides: was $51.00<a href="https://target.georiot.com/Proxy.ashx?tsid=110083&GR_URL=https%3A%2F%2Famazon.com%2FVital-Proteins-Collagen-Peptides-Pasture-Raised%2Fdp%2FB00K6JUG4K%3Ftag%3Dhawk-future-20%26ascsubtag%3Dhawk-custom-tracking-20" data-link-merchant="Amazon US"" target="_blank">now $32.49 at Amazon

Save $18.51. Vital Proteins Collagen Peptides Advanced is a premium offering with 20g collagen peptides per serving plus two additional functional ingredients: 100% daily value vitamin C and 80 mg hyaluronic acid. Vitamin C helps to support the body’s natural collagen production

Price check: <a href="https://goto.walmart.com/c/1943169/565706/9383?subId1=hawk-custom-tracking&sharedId=hawk&u=https%3A%2F%2Fwww.walmart.com%2Fip%2FVital-Proteins-Collagen-Peptides-Supplement-Powder-Unflavored-20-oz%2F350254837" data-link-merchant="walmart.com"" data-link-merchant="Amazon US"">Walmart $39.98 | <a href="https://goto.target.com/c/221109/81938/2092?subId1=hawk-custom-tracking&sharedId=hawk&u=https%3A%2F%2Fwww.target.com%2Fp%2Fvital-proteins-collagen-peptides-unflavored-powder-20oz%2F-%2FA-79524212" data-link-merchant="target.com"" data-link-merchant="walmart.com"" data-link-merchant="Amazon US"" target="_blank">Target $44.99 

Nature's Bounty Fish Oil Softgels: was $21.03now $12.95 at Amazon

Nature's Bounty Fish Oil Softgels: was $21.03, now <a href="https://target.georiot.com/Proxy.ashx?tsid=110083&GR_URL=https%3A%2F%2Famazon.com%2FNatures-Bounty-Supplement-Supporting-Cardiovascular%2Fdp%2FB000NPYY04%2Fref%3Dsr_1_6_mod_primary_new%3Ftag%3Dhawk-future-20%26ascsubtag%3Dhawk-custom-tracking-20" data-link-merchant="Amazon US"" target="_blank" rel="nofollow">$12.95 at Amazon 

Save 38%. Support your heart, aid your joints, and better your skin for less with these 200 fish oil capsules from Nature’s Bounty. If you buy these unflavored supplements today, you could save yourself more than $8.08 with 38% off. They contain no shellfish, gluten, lactose, or artificial colors and sweeteners. 

Centrum Multivitamin Silver Women 50+:was $11.99,now $10.48 at Amazon

Centrum Multivitamin Silver Women 50+: was $11.99, now <a href="https://target.georiot.com/Proxy.ashx?tsid=110083&GR_URL=https%3A%2F%2Famazon.com%2FCentrum-Multivitamin-Multimineral-Antioxidants-Ingredients%2Fdp%2FB08Y1KFYF8%2F%3Ftag%3Dhawk-future-20%26ascsubtag%3Dhawk-custom-tracking-20" data-link-merchant="Amazon US"" target="_blank" rel="nofollow">$10.48 at Amazon

Save 13% Our testers found the Centrum Multivitamin Silver Women 50+ was the <a target="_blank" href="https://www.fitandwell.com/buying-guides/best-vitamins-for-women-over-50" data-link-merchant="fitandwell.com"" data-link-merchant="Amazon US"">best vitamin for women over 50 to support their wellbeing. They liked the inclusion of calcium and vitamin D to help build and maintain healthy bones and found the price tag reasonable too. Even better, the 100-tablet tub is slightly cheaper than normal, with a nice 9% discount available right now.

Centrum Multivitamin Silver Men 50+:&nbsp;was $19.99,&nbsp;now $18.17 at Amazon

Centrum Multivitamin Silver Men 50+: was $19.99, now<a href="https://target.georiot.com/Proxy.ashx?tsid=110083&GR_URL=https%3A%2F%2Famazon.com%2FCentrum-Multivitamin-Multimineral-Supplement-Ingredients%2Fdp%2FB09KCD4D7F%2F%3Ftag%3Dhawk-future-20%26ascsubtag%3Dhawk-custom-tracking-20" data-link-merchant="Amazon US"" target="_blank" rel="nofollow"> $18.17 at Amazon

Save 9%. The twin of our top-rated multivitamin for women, this 200-tablet tub is now down from $19.99, saving you 9% on the regular price. You only need to take one a day, and it contains a variety of micronutrients, including vitamin D3, B vitamins, and zinc. 

Nature Made Vitamin B12 1000 mcg:&nbsp;was $23.89,&nbsp;now $9.48 at Amazon

Nature Made Vitamin B12 1000 mcg: was $23.89, now <a href="https://target.georiot.com/Proxy.ashx?tsid=110083&GR_URL=https%3A%2F%2Famazon.com%2FNature-Made-Vitamin-Softgels-Value%2Fdp%2FB00DS5BGDY%3Ftag%3Dhawk-future-20%26ascsubtag%3Dhawk-custom-tracking-20" data-link-merchant="Amazon US"" target="_blank">$9.48 at Amazon

Save $14.41 There's a hefty discount available on this bottle of 150 soft gel tablets. Supplementation with vitamin B12 is particularly important for vegetarians and vegans who may not get enough from diet alone. But with nearly 1000 mcg of B12 per capsule, there is no need to worry about nutritional deficiencies. 

Price check: <a href="https://goto.target.com/c/221109/81938/2092?subId1=hawk-custom-tracking&sharedId=hawk&u=https%3A%2F%2Fwww.target.com%2Fp%2Fnature-made-vitamin-b12-1000-mcg-energy-metabolism-support-time-release-tablets-75ct%2F-%2FA-14776645" data-link-merchant="target.com"" data-link-merchant="Amazon US"" target="_blank">Target $9.99,<a href="https://go.redirectingat.com/?id=92X1626907&xcust=hawk-custom-tracking&xs=1&url=https%3A%2F%2Fwww.naturemade.com%2Fproducts%2Fnature-made-vitamin-b12-1000-mcg-softgels&sref" data-link-merchant="SkimLinks - naturemade.com"" data-link-merchant="target.com"" data-link-merchant="Amazon US"" target="_blank"> Naturemade $23.89

Nature's Bounty Immune Support 24 Hour +:was $16.41now $10.98 at Amazon

Nature's Bounty Immune Support 24 Hour +: was $16.41now<a href="https://target.georiot.com/Proxy.ashx?tsid=110083&GR_URL=https%3A%2F%2Famazon.com%2FNatures-Bounty-Vitamin-Support-Softgels%2Fdp%2FB08KHZQTML%2F%3Ftag%3Dhawk-future-20%26ascsubtag%3Dhawk-custom-tracking-20" data-link-merchant="Amazon US"" target="_blank" rel="nofollow"> $10.98 at Amazon

Save 33% Don't miss out on this huge saving before the deal ends. Nature's Bounty Immune Support 24 Hour + is packed with immune-boosting ingredients, from a hefty 1000mg dose of vitamin C and zinc to extracts from Elderberry and Echinacea. This high quality supplement is free from dairy, sugar, gluten and artificial ingredients.  

Garden of Life Once Daily Dr. Formulated Probiotics for Women:&nbsp;was $39.95,&nbsp;now $30.61 at Amazon

Garden of Life Once Daily Dr. Formulated Probiotics for Women: was $39.95, now <a href="https://target.georiot.com/Proxy.ashx?tsid=110083&GR_URL=https%3A%2F%2Famazon.com%2FGarden-Life-Formulated-Probiotics-Guaranteed%2Fdp%2FB00Y8MP4G6%2F%3Ftag%3Dhawk-future-20%26ascsubtag%3Dhawk-custom-tracking-20" data-link-merchant="Amazon US"" target="_blank" rel="nofollow">$30.61 at Amazon

Save 23% on the Garden of Life Once Daily Dr. Formulated Probiotics for Women. With nearly 50 billion CFU of 16 diverse probiotic strains per serving, this supplement is uniquely designed to aid digestion, immune function and vaginal health in women. Free from gluten, dairy, soy and GMOs. 

Optimum Nutrition Opti-Men Multivitamin for Active Men:was $69.99now $29.99 at Amazon

Optimum Nutrition Opti-Men Multivitamin for Active Men: was $69.99now <a href="https://target.georiot.com/Proxy.ashx?tsid=110083&GR_URL=https%3A%2F%2Famazon.com%2FNUTRITION-Opti-Men-Multivitamin-Supplement-Vitamins%2Fdp%2FB00MEVITCY%3Ftag%3Dhawk-future-20%26ascsubtag%3Dhawk-custom-tracking-20" data-link-merchant="Amazon US"" target="_blank" rel="nofollow">$29.99 at Amazon

Save a massive 57% on the Optimum Nutrition Opti-Men, a top-rated multivitamin supplement formulated for active men. With nearly 25 vitamins and essential minerals, 1 gram of free form amino acids and a powerful blend of plant extracts and antioxidants, this supplement will supercharge your workouts, help with muscle recovery and boost your immune health.

Nature's Bounty Hair, Skin &amp; Nails Rapid Release Softgels:was $20.70,&nbsp;now $12.45 at Amazon

Nature's Bounty Hair, Skin & Nails Rapid Release Softgels: was $20.70, now<a href="https://target.georiot.com/Proxy.ashx?tsid=110083&GR_URL=https%3A%2F%2Famazon.com%2FNatures-Bounty-Multivitamin-Supplement-Antioxidants%2Fdp%2FB0072F8D7S%2F%3Ftag%3Dhawk-future-20%26ascsubtag%3Dhawk-custom-tracking-20" data-link-merchant="Amazon US"" target="_blank" rel="nofollow"> $12.45 at Amazon

Save 40% on the 50-day supply of Nature's Bounty Hair, Skin & Nails Rapid Release Softgels this Prime Day. Packed with vitamins, minerals, antioxidants and healthy oils, this supplement is designed to get the best out of your skin, hair and nails. Free from major allergens and artificial ingredients. 

Osteo Bi-Flex Triple Strength Joint Health Supplement: &nbsp;was $48.17,now $31.85 at Amazon

Osteo Bi-Flex Triple Strength Joint Health Supplement:  was $48.17, now<a href="https://target.georiot.com/Proxy.ashx?tsid=110083&GR_URL=https%3A%2F%2Famazon.com%2FOsteo-Bi-Flex-Strength-Vitamin-Tablets%2Fdp%2FB0055UFNQG%2F%3Ftag%3Dhawk-future-20%26ascsubtag%3Dhawk-custom-tracking-20" data-link-merchant="Amazon US"" target="_blank" rel="nofollow"> $31.85 at Amazon

Save 30% on the two-moth supply of the Osteo Bi-Flex Triple Strength is now half price at Amazon, a saving of nearly $15. Designed to support bone and joint health, this top-rated supplement includes vitamin D, glucosamine, chondroitin and a branded herbal extract. It's also free from gluten and GMOs.  

FAQs

When is Prime Day and is it only once a year?

The first 2023 Amazon Prime Day began on July 11 and ran until July 12—the second one is kicking off on October 10 and will end on October 11. The new event is technically called the Prime Big Deal sDay. 

The annual event started in 2015 as a celebration of Amazon's 20th anniversary and has since expanded to become a two-day sale where Prime subscribers can get additional discounts and savings on products across the entire range. 

Prime Day supplement deals: what to look out for

While you can get most nutrients from your diet, it's not always possible to get everything your body needs from food alone. If you can't add oily fish to your diet, there are so many benefits of fish oil that it's a good idea to use Prime Day to stock up on these omega-3 supplements. 

Similarly, if you eat a primarily plant-based or vegan diet, you may want to supplement your diet with vitamin B12, typically found in meat and other animal products. Our needs change over the years, so it's worth using supplements as you age, too but always seek advice from your doctor before taking a new supplement.

There may be discounts or savings on the best menopause supplements to help you manage hot flushes, mood swings, and night sweats as you go through menopause, while the best protein powder for women supports muscle growth and maintenance. 

When you exercise, small tears appear in your muscle fibers. Your body uses protein to repair these, and protein powders are a great way to ensure your muscles get everything they need to promote recovery and encourage muscle growth.

If you regularly train and home and you're looking to pick up some new equipment at a discount, make sure to check out our roundup of all the best Prime Day weights deals to save on kettlebells, dumbbells, and barbells. 

How to find good Prime Day supplement deals

To get the most from Prime Day supplement deals, it's worth considering what type of supplement would best support your body. If you're unsure, talk to your doctor or healthcare provider about your specific needs.

Supplements are usually branded or marketed towards certain lifestyles. These might be just what you need, but if you're after a vitamin D supplement, you might not need a more comprehensive multi-vitamin.

If you eat a vegan diet, then fish oil supplements and B12 vitamins are a good way to top up your nutrient levels, but be sure to look out for brands that specifically mention that they are vegan-friendly, as not all supplements are.

When searching for a Prime Day supplement deal, price is often a significant consideration. Before we feature any deals, we investigate historical prices, compare them against other retailers, and put them into context so you can make an informed choice.

James Frew
Fitness Editor

James is a London-based journalist and Fitness Editor at Fit&Well. He has over five years experience in fitness tech, including time spent as the Buyer’s Guide Editor and Staff Writer at technology publication MakeUseOf. In 2014 he was diagnosed with a chronic health condition, which spurred his interest in health, fitness, and lifestyle management.


In the years since, he has become a devoted meditator, experimented with workout styles and exercises, and used various gadgets to monitor his health. In recent times, James has been absorbed by the intersection between mental health, fitness, sustainability, and environmentalism. When not concerning himself with health and technology, James can be found excitedly checking out each week’s New Music Friday releases.


With contributions from